Chapel Hill, NC
Preparation Guide

Blood Protein Preparation

Everything you need to know before and after your Alpha-2-Macroglobulin protein concentrate treatment.

60-90 min
Procedure Time
1 week
Stop NSAIDs Before
24-48 hrs
Rest Period After
2-6 weeks
Results Timeline

Understanding Blood Protein Concentrate Treatment

A2M (Alpha-2-Macroglobulin) is a powerful protein found naturally in your blood that helps protect cartilage from destructive enzymes. Like PRP, A2M is derived from your own blood, making it a safe, autologous treatment.

Similar to PRP Preparation

Blood protein therapy preparation is very similar to PRP therapy. The procedure involves drawing blood, processing it to concentrate the blood proteins, and injecting the concentrate into the affected area. The same guidelines for medication restrictions, hydration, and recovery apply.

See detailed PRP preparation guide

Before Your Treatment

7
One Week Before

  • Stop NSAIDs

    Ibuprofen, naproxen, aspirin, celecoxib — these interfere with healing.

  • Tylenol is okay

    Acetaminophen is safe to use if needed for pain.

Day Before & Day Of

  • Stay well hydrated — easier blood draw
  • Eat a healthy meal — don't fast
  • Avoid alcohol — affects blood quality
  • Arrange a driver — for lower extremity treatments

After Your Treatment

First 48 Hours

  • Rest the treated area — avoid strenuous activity
  • Light walking is fine
  • Use Tylenol for discomfort (no NSAIDs)
  • Ice if needed for swelling (15-20 min)

First 2 Weeks & Beyond

  • Continue avoiding NSAIDs for 2 weeks
  • Gradually increase activity as tolerated
  • Results develop over 2-6 weeks
  • Full benefits may continue over 2-3 months

What's Normal After A2M

Mild soreness, swelling, or warmth at the injection site is normal and typically resolves within a few days. Minor bruising at the blood draw site is also common. Contact us if you experience fever, severe pain, or signs of infection.

Questions About A2M Therapy?

Contact us with any questions about preparing for your blood protein concentrate treatment.