Chapel Hill, NC
Evidence-Based Medicine

References & Related Publications

Our treatments are grounded in peer-reviewed scientific research. Below you'll find key publications supporting the regenerative medicine therapies we offer.

29+ Publications
Peer-Reviewed Research
NIH & DoD Funded
Research Support

Dr. Buchheit's Publications

Research authored by Dr. Thomas Buchheit, MD

1

Autologous Conditioned Plasma is not Platelet-Rich Plasma

Buchheit T, Hunt C, Eldrige J, Eshraghi Y, Souza D

Reg Anesth Pain Med 2026
Journal Article
2

Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group

D'Souza, R. S., Y. F. Her, N. Hussain, J. Karri, M. E. Schatman, A. K. Calodney, C. Lam, T. Buchheit et al

J Pain Research Vol. 17 pp. 49 2024
Journal Article
3

Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes

Buchheit T, Huh Y, Breglio A, Bang S, Xu J, Matsuoka Y, et al.

Brain, Behavior, and Immunity Vol. 111 pp. 298-311 2023
Journal Article View DOI
4

Platelet-rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain

Buchheit T

Neuroimmune Interactions in Pain: Mechanisms and Therapeutics pp. 287-304 2023
Book Chapter
5

Product characteristics should be reported in all biological therapy publications

30. Buchheit T, Hunt C, Eldrige J, Eshraghi Y, Souza D

Reg Anesth Pain Med Vol. 47(7) 2022
Journal Article
6

Neuroimmune modulation of pain and regenerative pain medicine

Buchheit T, Huh Y, Maixner W, Cheng J, Ji RR

Journal of Clinical Investigation Vol. 130(5) pp. 2164-76 2020
Journal Article View DOI
7

Future therapies and the expanding role for diagnostic ultrasound

Buchheit T

Curr Opin Anaesthesiol Vol. 5 pp. 2 2016
Journal Article

Related Research

Peer-reviewed studies supporting our treatment approaches

8

Influence of Platelet Concentration on the Clinical Outcome of Platelet-Rich Plasma Injections in Knee Osteoarthritis

Boffa A, De Marziani L, Andriolo L, Di Martino A, Romandini I, Zaffagnini S, et al.

American Journal of Sports Medicine Vol. 52(13) pp. 3223-31 2024
PRP Research
9

The Long-Term Analgesic Effectiveness of Platelet-Rich Plasma Injection for Carpal Tunnel Syndrome: A Cross-Sectional Cohort Study

Lai CY, Li TY, Lam KHS, Chou YC, Hueng DY, Chen LC, et al.

Pain Medicine Vol. 23(7) pp. 1249-58 2022
PRP Research View DOI
10

Efficacy of 5% Dextrose Water Injection for Peripheral Entrapment Neuropathy: A Narrative Review

Wu YT, Wu CH, Lin JA, Su DC, Hung CY, Lam SKH

International Journal of Molecular Sciences Vol. 22(22) 2021
Hydrodissection View DOI
11

Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function

Xu Z, He Z, Shu L, Li X, Ma M, Ye C

Arthroscopy Vol. 37(3) pp. 903-15 2021
PRP Research View DOI
12

Effect of Platelet-Rich Plasma Injection on Mild or Moderate Carpal Tunnel Syndrome: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dong C, Sun Y, Qi Y, Zhu Y, Wei H, Wu D, et al.

BioMed Research International Vol. 2020 pp. 5089378 2020
PRP Research View DOI
13

Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study

Snoeker B, Turkiewicz A, Magnusson K, Frobell R, Yu D, Peat G, et al.

British Journal of Sports Medicine Vol. 54(12) pp. 725-30 2020
Injury Research View DOI
14

The Effectiveness and Safety of Commonly Used Injectates for Ultrasound-Guided Hydrodissection Treatment of Peripheral Nerve Entrapment Syndromes: A Systematic Review

Buntragulpoontawee M, Chang KV, Vitoonpong T, Pornjaksawan S, Kitisak K, Saokaew S, et al.

Frontiers in Pharmacology Vol. 11 pp. 621150 2020
Hydrodissection View DOI
15

Long-term rates of knee arthroplasty in a cohort of 834,393 patients with a history of arthroscopic partial meniscectomy

Abram SGF, Judge A, Beard DJ, Carr AJ, Price AJ

Bone & Joint Journal Vol. 101-b(9) pp. 1071-80 2019
Surgery Outcomes View DOI
16

Low level laser therapy for the patients with painful diabetic peripheral neuropathy – A systematic review

Anuj M, Ummer VS, Maiya AG, Hande M

Diabetes & Metabolic Syndrome: Clinical Research & Reviews Vol. 13(4) pp. 2667-70 2019
Laser Therapy View DOI
17

Management of Chronic Tendon Injuries

Kane SF, Olewinski LH, Tamminga KS

American Family Physician Vol. 100(3) pp. 147-57 2019
Tendon Treatment
18

The efficacy and safety of autologous conditioned serum (ACS) injections compared with betamethasone and placebo injections in the treatment of chronic shoulder joint pain due to supraspinatus tendinopathy: a prospective, randomized, double-blind, controlled study

Damjanov N, Barac B, Colic J, Stevanovic V, Zekovic A, Tulic G

Medical Ultrasonography Vol. 20(3) pp. 335-41 2018
ACS/Regenokine View DOI
19

L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain

Cruccu G, Di Stefano G, Fattapposta F, Jann S, Padua L, Schenone A, et al.

CNS Drugs Vol. 31(12) pp. 1103-11 2017
Supplements View DOI
20

Partial meniscectomy is associated with increased risk of incident radiographic osteoarthritis and worsening cartilage damage in the following year

Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Grago J, et al.

European Radiology Vol. 27(1) pp. 404-13 2017
Surgery Outcomes View DOI
21

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial

Argenta PA, Ballman KV, Geller MA, Carson LF, Ghebre R, Mullany SA, et al.

Gynecologic Oncology Vol. 144(1) pp. 159-66 2017
Laser Therapy View DOI
22

Effectiveness of High Intensity Laser Therapy for Reduction of Pain in Knee Osteoarthritis

Angelova A, Ilieva EM

Pain Research and Management Vol. 2016 pp. 9163618 2016
Laser Therapy View DOI
23

Identification of alpha2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis

Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, et al.

Arthritis & Rheumatology Vol. 66(7) pp. 1843-53 2014
A2M Protein View DOI
24

OARSI guidelines for the non-surgical management of knee osteoarthritis

McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al.

Osteoarthritis and Cartilage Vol. 22(3) pp. 363-88 2014
Clinical Guidelines View DOI
25

Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial

Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, et al.

Annals of Family Medicine Vol. 11(3) pp. 229-37 2013
Prolotherapy View DOI
26

Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial

Ghoreishi Z, Esfahani A, Djazayeri A, Djalali M, Golestan B, Ayromlou H, et al.

BMC Cancer Vol. 12 pp. 355 2012
Supplements View DOI
27

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis

Baltzer AWA, Moser C, Jansen SA, Krauspe R

Osteoarthritis and Cartilage Vol. 17(2) pp. 152-60 2009
ACS/Regenokine View DOI
28

Efficacy of Epidural Perineural Injections With Autologous Conditioned Serum for Lumbar Radicular Compression

Becker C, Heidersdorf S, Drewlo S, Rodriguez SZd, Krämer J, Willburger RE

Spine Vol. 32(17) pp. 1803-8 2007
ACS/Regenokine View DOI
29

The targeting accuracy of subacromial injection to the shoulder: an arthrographic evaluation

Yamakado K

Arthroscopy Vol. 18(8) pp. 887-91 2002
Injection Technique View DOI

Research by Treatment Area

Our evidence base spans multiple regenerative medicine modalities

PRP

4 studies

ACS/Regenokine

4 studies

Cold Laser Therapy

3 studies

Hydrodissection

2 studies

A2M Protein

1 study

Supplements

2 studies

Learn More in Dr. Buchheit's Book

Healing Joints and Nerves: Immune Stimulation and the New Science of Regenerative Therapies provides an in-depth look at the science behind our treatments.

Written for patients who want to understand how regenerative medicine works and why it offers hope for those with chronic joint and nerve pain.

Healing Joints and Nerves book cover

Ready to Explore Evidence-Based Treatments?

Schedule a consultation with Dr. Buchheit to discuss how regenerative medicine can help you.