Chapel Hill, NC
Stimulate Natural Healing

Prolotherapy

Prolotherapy (proliferative therapy) uses natural dextrose solutions to stimulate your body's own healing response. By triggering a controlled inflammatory reaction, prolotherapy recruits growth factors and healing cells to repair damaged ligaments, tendons, and joints.

A time-tested approach for chronic pain, joint instability, and soft tissue injuries that haven't responded to other treatments.

How Prolotherapy Works

Prolotherapy works by harnessing your body's natural healing mechanisms. When a concentrated dextrose solution is injected into damaged or weakened tissue, it creates a mild irritation that triggers an inflammatory response.

This controlled inflammation signals your body to send healing cells, growth factors, and new collagen to the area — essentially restarting the healing process in tissues that have stopped healing on their own.

Over a series of treatments, this process progressively strengthens ligaments, tendons, and joint structures, leading to improved stability and reduced pain.

The Healing Cascade

1

Controlled Irritation

Dextrose solution creates mild tissue irritation at the injection site.

2

Inflammatory Response

Your body responds by sending healing cells and growth factors to the area.

3

Tissue Repair

New collagen is laid down, strengthening weakened ligaments and tendons.

4

Progressive Strengthening

Each treatment session builds on the last for cumulative improvement.

Conditions Treated with Prolotherapy

Prolotherapy is particularly effective for chronic pain from ligament and tendon injuries

Joint Instability

Loose or hypermobile joints from ligament laxity, including chronic ankle sprains and knee instability.

Chronic Tendon Pain

Tennis elbow, golfer's elbow, Achilles tendinopathy, and other stubborn tendon conditions.

Spinal Pain

Facet joint pain, sacroiliac dysfunction, and chronic low back pain from ligament weakness.

Osteoarthritis

Knee, hip, and hand arthritis — research shows improvement in pain and function.

Plantar Fasciitis

Chronic heel pain that hasn't responded to conservative treatments.

Rotator Cuff Injuries

Partial tears and chronic shoulder pain from weakened tendons.

The Prolotherapy Procedure

A straightforward office procedure with minimal downtime

1

Assessment

Dr. Buchheit examines the area and uses ultrasound to identify damaged structures.

2

Preparation

The treatment area is cleaned and may be numbed with local anesthetic for comfort.

3

Injection

Dextrose solution is precisely injected into the damaged ligaments, tendons, or joint.

4

Recovery

Brief observation, then you're on your way. Expect some soreness for 24-72 hours.

Treatment Series

Unlike single-treatment procedures, prolotherapy works best as a series. Most patients receive 3-6 treatments spaced 2-4 weeks apart. Each session builds on the previous one, progressively strengthening the treated tissues.

Some patients notice improvement after the first few sessions, while others see gradual progress throughout the series. The total number of treatments depends on your specific condition and response.

3-6
Typical sessions
2-4
Weeks between

Starting Prolotherapy?

View our complete preparation guide including medication guidelines and what to expect after each session.

View Prolotherapy Prep Guide

Prolotherapy vs. Other Options

vs. Cortisone

Cortisone suppresses inflammation for temporary relief but can weaken tissues over time. Prolotherapy stimulates actual tissue repair and strengthening.

Prolotherapy: Heals rather than masks

vs. PRP

Both are regenerative, but PRP uses concentrated platelets while prolotherapy uses dextrose. PRP may be more potent; prolotherapy is more affordable. They can be combined.

Prolotherapy: Cost-effective option

vs. Surgery

Surgery requires significant downtime and carries risks. Prolotherapy is minimally invasive with no surgical recovery. Many patients avoid surgery entirely.

Prolotherapy: Non-surgical approach

Frequently Asked Questions

Some discomfort during injections is expected, but we use techniques to minimize pain. More importantly, temporary soreness and stiffness for 24-72 hours after treatment is normal and actually indicates the therapy is working. This post-treatment discomfort typically resolves and is followed by progressive improvement.

Most conditions require 3-6 treatment sessions, spaced 2-4 weeks apart. Some patients need more sessions depending on the severity and chronicity of their condition. We'll develop a treatment plan based on your specific situation and adjust based on your response.

Some patients notice improvement after the first 2-3 sessions, while others experience gradual progress throughout the series. Full benefits typically develop over several months as the strengthened tissues mature. Patience is important — prolotherapy works by stimulating real tissue repair.

Prolotherapy is typically not covered by insurance. However, it's one of our most affordable treatments, and many patients find it cost-effective compared to ongoing medications, repeated cortisone injections, or surgery. We provide transparent pricing and can give you a statement for your records.

Yes! Prolotherapy combines well with other regenerative therapies. We sometimes use it with PRP for enhanced healing, or with nerve hydrodissection for complex cases. Physical therapy between sessions can also improve outcomes. We'll recommend the best approach for your condition.

Ready to Start Healing?

Find out if prolotherapy can help your chronic pain. Schedule a consultation to discuss your options.

Other Treatments We Offer